Lekárske štúdie a výsledky nukleárnej terapie

Kolenný kĺb pred terapiou a po terapii

Necrosis knee joint

Disc Herniation L5-S1

Rupture M. teres major

Musculus internus / externus obliquus

MRT Study German Sport University Cologne 1998

Univ. Prof. Dr. Ingo Froboese

Quantification of the cartilage structures

Štúdie na stiahnutie

Najnovšie lekárske štúdie preukázali, že práve špecifické elektromagnetické polia využívané pri nukleárnej terapii môžu okrem iného  :

– zvyšovať osteogénnu i chondrogénnu diferenciáciu mezenchymálnych kmeňových buniek (tvorbu kostných a chrupavkových buniek)

– enormne zvyšovať expresiu kolagénu typu II (Col2) a obsah glykozaminoglykánu 

–  pôsobiť ako chemotaktický signál pre kmeňové bunky a chondrocyty, čím podporujú migráciu buniek na miesto poškodenia, aby sa podporila oprava poškodeného tkaniva

– majú silný protizápalový účinok, ktorý chráni tkanivo chrupavky pred katabolickou aktivitou prozápalových cytokínov

–  stimulujú signálnu dráhu Wnt, ktorá sa bežne aktivuje počas hojenia kostí a o ktorej je tiež známe, že sa podieľa na diferenciácii kostných buniek a procesoch opravy kostí. 

Výber z lekárskych štúdií :

Pulsed electromagnetic fields stimulate osteogenic differentiation in human    bone marrow and adipose tissue derived mesenchymal stem cells

Alessia Ongaro ¹, Agnese Pellati, Leila Bagheri, Cinzia Fortini, Stefania Setti, Monica De Mattei

https://www.researchgate.net/publication/268747712_Biological_effects_of_pulsating_magnetic_fields_role_of_solitons

  
Pulsed electromagnetic fields accelerate proliferation and osteogenic gene expression in human bone marrow mesenchymal stem cells during osteogenic differentiation.

Sun LY, Hsieh DK, Lin PC, Chiu HT, Chiou TW.Bioelectromagnetics. 2010 Apr;31(3):209-19. doi: 10.1002/bem.20550.PMID: 19866474

  Effect of pulsed electromagnetic field therapy on the osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells.

Lu T, Huang YX, Zhang C, Chai MX, Zhang J.Genet Mol Res. 2015 Sep 28;14(3):11535-42. doi: 10.4238/2015.September.28.5.PMID: 26436394

• A Novel Method to Achieve Precision and Reproducibility in Exposure Parameters for Low-Frequency Pulsed Magnetic Fields in Human Cell Cultures.

Ronniger M, Aguida B, Stacke C, Chen Y, Ehnert S, Erdmann N, Eschenburg G, Falldorf K, Pooam M, Wing A, Ahmad M.Bioengineering (Basel). 2022 Oct 21;9(10):595. doi: 10.3390/bioengineering9100595.PMID: 36290562 

• Pulsed electromagnetic fields inhibit mandibular bone deterioration depending on the Wnt3a/β-catenin signaling activation in type 2 diabetic db/db mice.

Li J, Cai J, Liu L, Wu Y, Chen Y.Sci Rep. 2022 May 4;12(1):7217. doi: 10.1038/s41598-022-10065-7.PMID: 35508623 

• Pulsed electromagnetic fields as a promising therapy for glucocorticoid-induced osteoporosis.

Zhang T, Zhao Z, Wang T.Front Bioeng Biotechnol. 2023 Mar 3;11:1103515. doi: 10.3389/fbioe.2023.1103515. eCollection 2023.PMID: 36937753 

Pulsed electromagnetic fields prevent osteoporosis in an ovariectomized female rat model: a prostaglandin E2-associated process

Kyle Chang ¹, Walter Hong-Shong Chang

• Circadian rhythm affects the preventive role of pulsed electromagnetic fields on ovariectomy-induced osteoporosis in rats.

Jing D, Shen G, Huang J, Xie K, Cai J, Xu Q, Wu X, Luo E.Bone. 2010 Feb;46(2):487-95. doi: 10.1016/j.bone.2009.09.021. Epub 2009 Sep 25.PMID: 19782781

• Pulsed electromagnetic fields stimulation affects BMD and local factor production of rats with disuse osteoporosis.

Shen WW, Zhao JH.Bioelectromagnetics. 2010 Feb;31(2):113-9. doi: 10.1002/bem.20535.PMID: 19670410

• [Effect of low frequency pulsed electromagnetic fields on lumbar bone histomorphometry in ovariectomized osteoporosis rats].

Chen J, Huang L, Hu Y, He C.Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2011 Dec;25(12):1455-8.PMID: 22242344 Chinese.

• The effect of long-term pulsing electromagnetic field stimulation on experimental osteoporosis of rats.

Mishima S.J UOEH. 1988 Mar 1;10(1):31-45. doi: 10.7888/juoeh.10.31.PMID: 3285429 Review.

• Ovariectomized rat model of osteoporosis: a practical guide.

Yousefzadeh N, Kashfi K, Jeddi S, Ghasemi A.EXCLI J. 2020 Jan 10;19:89-107. doi: 10.17179/excli2019-1990. eCollection 2020.PMID: 32038119 Free PMC article. Review.

• The effects of low-intensity pulsed ultrasound and pulsed electromagnetic fields bone growth stimulation in acute fractures: a systematic review and meta-analysis of randomized controlled trials.

Hannemann PF, Mommers EH, Schots JP, Brink PR, Poeze M.Arch Orthop Trauma Surg. 2014 Aug;134(8):1093-106. doi: 10.1007/s00402-014-2014-8. Epub 2014 Jun 4.PMID: 24895156 Review.

• Low frequency pulsed electromagnetic field–a viable alternative therapy for arthritis.

Ganesan K, Gengadharan AC, Balachandran C, Manohar BM, Puvanakrishnan R.Indian J Exp Biol. 2009 Dec;47(12):939-48.PMID: 20329696 Review.

• Evolution of magnetic therapy from alternative to traditional medicine.

Vallbona C, Richards T.Phys Med Rehabil Clin N Am. 1999 Aug;10(3):729-54.PMID: 10516987 Review.

• Pulsed electromagnetic field treatment failure in radius non-united fracture healing.

Madroñero A, Pitillas I, Manso FJ.J Biomed Eng. 1988 Oct;10(5):463-6. doi: 10.1016/0141-5425(88)90153-7.PMID: 3266277

• Treatment of delayed- and non-union of fractures using pulsed electromagnetic fields.

Colson DJ, Browett JP, Fiddian NJ, Watson B.J Biomed Eng. 1988 Jul;10(4):301-4. doi: 10.1016/0141-5425(88)90058-1.PMID: 3266275

Pulsed electromagnetic fields for the treatment of bone fractures

               A Satter Syed ¹, M S Islam, K S Rabbani, M S Talukder

• Electrical stimulation in bone healing: critical analysis by evaluating levels of evidence.

Griffin M, Bayat A.Eplasty. 2011;11:e34. Epub 2011 Jul 26.PMID: 21847434

• The preventive effects of pulsed electromagnetic fields on diabetic bone loss in streptozotocin-treated rats.

Jing D, Cai J, Shen G, Huang J, Li F, Li J, Lu L, Luo E, Xu Q.Osteoporos Int. 2011 Jun;22(6):1885-95. doi: 10.1007/s00198-010-1447-3. Epub 2010 Oct 26.PMID: 20976595

• Pulsed electromagnetic stimulation in nonunion of tibial diaphyseal fractures.

Gupta AK, Srivastava KP, Avasthi S.Indian J Orthop. 2009 Apr;43(2):156-60. doi: 10.4103/0019-5413.50850.PMID: 19838364 

• Low-intensity pulsed ultrasound and pulsed electromagnetic field in the treatment of tibial fractures: a systematic review.

Walker NA, Denegar CR, Preische J.J Athl Train. 2007 Oct-Dec;42(4):530-5.PMID: 18174942 

• Effects of ultra-wideband electromagnetic pulses on pre-neoplastic mammary epithelial cell proliferation.

Sylvester PW, Shah SJ, Haynie DT, Briski KP.Cell Prolif. 2005 Jun;38(3):153-63. doi: 10.1111/j.1365-2184.2005.00340.x.PMID: 15985060 

  Co-Culture with Human Osteoblasts and Exposure to Extremely Low Frequency Pulsed Electromagnetic Fields Improve Osteogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells.

Ehnert S, van Griensven M, Unger M, Scheffler H, Falldorf K, Fentz AK, Seeliger C, Schröter S, Nussler AK, Balmayor ER.Int J Mol Sci. 2018 Mar 27;19(4):994. doi: 10.3390/ijms19040994.PMID: 29584629 

  Impact of Age on Human Adipose Stem Cells for Bone Tissue Engineering.

Dufrane D.Cell Transplant. 2017 Sep;26(9):1496-1504. doi: 10.1177/0963689717721203.PMID: 29113460 

  Osteogenic potential: Comparison between bone marrow and adipose-derived mesenchymal stem cells.

Liao HT, Chen CT.World J Stem Cells. 2014 Jul 26;6(3):288-95. doi: 10.4252/wjsc.v6.i3.288.PMID: 25126378 

Promising application of Pulsed Electromagnetic Fields (PEMFs) in musculoskeletal disorders

Author links open overlay panelHongzhi Hu ^a c 1, Wenbo Yang ^a 1, Qianwen Zeng ^b 1, Wei Chen ^c, YanBin Zhu ^c, Weijian Liu ^a, Shangyu Wang ^a, Baichuan Wang ^a, Zengwu Shao ^a, Yingze Zhang ^a c

• Energizing Healing with Electromagnetic Field Therapy in Musculoskeletal Disorders.

Rajalekshmi R, Agrawal DK.J Orthop Sports Med. 2024;6(2):89-106. doi: 10.26502/josm.511500147. Epub 2024 May 17.PMID: 39036742 

A comparative study of the effects of magnetic stimulation and electric stimulation on peripheral nerve injury in rat

A Bannaga ¹, T Guo, X Ouyang, D Hu, C Lin, F Cao, Y Dun, Z Guo

• Magnetic stimulation accelerating rehabilitation of peripheral nerve injury.

Bannaga A, Guo T, Ouyang X, Hu D, Lin C, Cao F, Deng Y, Guo Z, Luo Y.J Huazhong Univ Sci Technolog Med Sci. 2002;22(2):135-9. doi: 10.1007/BF02857676.PMID: 12658756

• Effectiveness of electrical stimulation on nerve regeneration after crush injury: Comparison between invasive and non-invasive stimulation.

Ju C, Park E, Kim T, Kim T, Kang M, Lee KS, Park SM.PLoS One. 2020 May 26;15(5):e0233531. doi: 10.1371/journal.pone.0233531. eCollection 2020.PMID: 32453807 

• Electrical stimulation impairs early functional recovery and accentuates skeletal muscle atrophy after sciatic nerve crush injury in rats.

Gigo-Benato D, Russo TL, Geuna S, Domingues NR, Salvini TF, Parizotto NA.Muscle Nerve. 2010 May;41(5):685-93. doi: 10.1002/mus.21549.PMID: 20405500

• Effects of electroacupuncture on functional indices and pS6 expression following acute sciatic nerve crush injury in rats.

Zeng L, Cen Y, Chen J, Lei L, Zhang L, Qin X, Gao X, Wang Y, Zeng C.Acupunct Med. 2020 Jun;38(3):181-187. doi: 10.1136/acupmed-2016-011263. Epub 2020 Jan 30.PMID: 31996011

• Functional assessment after sciatic nerve injury in a rat model.

Dinh P, Hazel A, Palispis W, Suryadevara S, Gupta R.Microsurgery. 2009;29(8):644-9. doi: 10.1002/micr.20685.PMID: 19653327

Effect of pulsed electromagnetic stimulation on facial nerve regeneration

J M Byers ¹, K F Clark, G C Thompson

• Effect of platelet rich plasma and fibrin sealant on facial nerve regeneration in a rat model.

Farrag TY, Lehar M, Verhaegen P, Carson KA, Byrne PJ.Laryngoscope. 2007 Jan;117(1):157-65. doi: 10.1097/01.mlg.0000249726.98801.77.PMID: 17202946

• Bacterial cellulose tubes as a nerve conduit for repairing complete facial nerve transection in a rat model.

Binnetoglu A, Demir B, Akakin D, Kervancioglu Demirci E, Batman C.Eur Arch Otorhinolaryngol. 2020 Jan;277(1):277-283. doi: 10.1007/s00405-019-05637-9. Epub 2019 Oct 8.PMID: 31595316

• Whisking recovery after automated mechanical stimulation during facial nerve regeneration.

Kleiss IJ, Knox CJ, Malo JS, Marres HA, Hadlock TA, Heaton JT.JAMA Facial Plast Surg. 2014 Mar-Apr;16(2):133-9. doi: 10.1001/jamafacial.2013.2217.PMID: 24407357 

• Putative roles of soluble trophic factors in facial nerve regeneration, target reinnervation, and recovery of vibrissal whisking.

Bendella H, Rink S, Grosheva M, Sarikcioglu L, Gordon T, Angelov DN.Exp Neurol. 2018 Feb;300:100-110. doi: 10.1016/j.expneurol.2017.10.029. Epub 2017 Nov 8.PMID: 29104116 Review.

• Prospects on clinical applications of electrical stimulation for nerve regeneration.

Sisken BF, Walker J, Orgel M.J Cell Biochem. 1993 Apr;51(4):404-9. doi: 10.1002/jcb.2400510404.PMID: 8496243 Review.